Gender has been central to Isabelle Grosse's work since her 2018 series "Powder Room Guys," where she used a documentary style to capture moments of vulnerability and softness among men in the private space of the bathroom. She later turned to more exuberant and theatrical expressions of gender, as seen in drag culture and voguing. Throughout her practice, she explores gender as performance—a concept articulated by Judith Butler. Her series frequently go beyond pure photography, incorporating written testimonies that add depth and context to the images.